{"title":"Enzymes","description":"\u003cp\u003eWritten by the Plenthera team (trained in orthomolecular nutrition). Scientifically reviewed in May 2026. Last updated: 18 September 2026.\u003c\/p\u003e\n\u003cp\u003eEnzymes are catalysts — proteins that speed up specific biochemical reactions without being used up themselves. The human body produces thousands of them, but the enzyme supplement category focuses on two groups: digestive enzymes (bromelain, papain, amylase, lipase, protease, lactase) and systemic enzymes (nattokinase, serrapeptase, lumbrokinase), which are taken on an empty stomach and are being studied in connection with circulation and tissue repair.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOn this page\u003c\/strong\u003e \u003ca href=\"#spijsverteringsenzymen\"\u003eDigestive enzymes — what for and when?\u003c\/a\u003e · \u003ca href=\"#systemische-enzymen\"\u003eSystemic enzymes — taken on an empty stomach\u003c\/a\u003e · \u003ca href=\"#subcategorieen\"\u003eOur enzyme subcategories and brands\u003c\/a\u003e · \u003ca href=\"#faq\"\u003eFrequently asked questions\u003c\/a\u003e · \u003ca href=\"#combineren\"\u003eCombine with\u003c\/a\u003e · \u003ca href=\"#bronnen\"\u003eSources\u003c\/a\u003e\u003c\/p\u003e\n\u003ch2 id=\"spijsverteringsenzymen\"\u003eDigestive enzymes — what for and when?\u003c\/h2\u003e\n\u003cp\u003eDigestive enzymes break down carbohydrates (amylase), fats (lipase), proteins (protease) and fibre (cellulase). They are widely used around heavy meals, when digestive capacity declines with age, or for specific intolerances: bromelain and papain as a plant-based source of protease and lactase for lactose. For lactase there is an authorised EFSA claim: \u003cem\u003elactase enzyme improves lactose digestion in individuals who have difficulty digesting lactose\u003c\/em\u003e (for food supplements with at least 4,500 FCC units per dose, to be taken with each lactose-containing meal; lactose tolerance varies from person to person — seek advice on its role in your diet). For the other enzymes we describe the mechanism and research context.\u003c\/p\u003e\n\u003cp\u003eIntake: usually just before or at the start of the meal, 1-2 capsules. With heavy meals possibly 2 capsules; not needed with light snacks.\u003c\/p\u003e\n\u003ch2 id=\"systemische-enzymen\"\u003eSystemic enzymes — taken on an empty stomach\u003c\/h2\u003e\n\u003cp\u003eSystemic enzymes (nattokinase, serrapeptase, lumbrokinase) are taken on an empty stomach — at least 30 minutes before or 2 hours after a meal — so that they are not used up in digesting food. They are being studied in connection with fibrin breakdown (fibrinolysis) and circulation.\u003c\/p\u003e\n\u003ch3\u003eNattokinase\u003c\/h3\u003e\n\u003cp\u003eDerived from natto (a fermented soy product). Studied in connection with fibrin breakdown and blood circulation. Often used at a dose of 2,000 FU per day.\u003c\/p\u003e\n\u003ch3\u003eSerrapeptase\u003c\/h3\u003e\n\u003cp\u003eA protease obtained from Serratia bacteria. Being studied in connection with recovery after exertion.\u003c\/p\u003e\n\u003ch3\u003eLumbrokinase\u003c\/h3\u003e\n\u003cp\u003eA powerful systemic enzyme, originally isolated from earthworms. Mainly studied in a cardiovascular context.\u003c\/p\u003e\n\u003ch2 id=\"subcategorieen\"\u003eOur enzyme subcategories and brands\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"\/en-pt\/collections\/spijsverteringsenzymen\"\u003eDigestive enzymes\u003c\/a\u003e — \u003cem\u003ebroad enzyme blends for food digestion\u003c\/em\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/en-pt\/collections\/bromelaine\"\u003eBromelain\u003c\/a\u003e — \u003cem\u003efrom pineapple — protease for protein digestion, studied around recovery\u003c\/em\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/en-pt\/collections\/amylase\"\u003eAmylase\u003c\/a\u003e — \u003cem\u003efor carbohydrate digestion\u003c\/em\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/en-pt\/collections\/lipase\"\u003eLipase\u003c\/a\u003e — \u003cem\u003efor fat digestion\u003c\/em\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/en-pt\/collections\/protease\"\u003eProtease\u003c\/a\u003e — \u003cem\u003efor protein digestion\u003c\/em\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/en-pt\/collections\/lactase\"\u003eLactase\u003c\/a\u003e — \u003cem\u003efor those who have difficulty digesting lactose (EFSA claim)\u003c\/em\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/en-pt\/collections\/nattokinase\"\u003eNattokinase\u003c\/a\u003e — \u003cem\u003esystemic enzyme from natto, studied in a cardiovascular context\u003c\/em\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/en-pt\/collections\/lumbrokinase\"\u003eLumbrokinase\u003c\/a\u003e — \u003cem\u003epowerful systemic fibrinolytic enzyme\u003c\/em\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/en-pt\/collections\/arthur-andrew-medical\"\u003eArthur Andrew Medical\u003c\/a\u003e — \u003cem\u003eAmerican enzyme specialist brand (Neprinol, Serretia, Devigest)\u003c\/em\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 id=\"faq\"\u003eFrequently asked questions\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eWhat is the difference between digestive and systemic enzymes?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eDigestive enzymes are taken with a meal to break down food in the digestive tract. Systemic enzymes are taken on an empty stomach — they are absorbed and studied for their action in blood and tissue on fibrin and circulation.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhen do I take digestive enzymes?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eJust before or at the start of the meal. With heavy (protein- or fat-rich) meals, the contribution of enzymes is greatest.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAre enzymes safe for long-term use?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eDigestive enzymes are generally considered safe. Systemic enzymes (nattokinase, serrapeptase, lumbrokinase) are not recommended if you use blood thinners or before surgery — always consult a doctor.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhat does bromelain do?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBromelain is a protease from pineapple. Taken with a meal it breaks down proteins; taken on an empty stomach it is being studied in connection with recovery after exertion.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCan I combine enzymes with other supplements?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eDigestive enzymes are often combined with live cultures (probiotics) as a complete digestive package. Do not combine systemic enzymes with blood thinners. If in doubt: ask your GP or pharmacist.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhich brand of enzymes is best?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eArthur Andrew Medical (AAM) specialises in enzyme formulas with standardised activity units (FU, SPU, GDU). Vitals and NOW Foods also supply reliable digestive enzymes.\u003c\/p\u003e\n\u003ch2 id=\"combineren\"\u003eCombine with other categories\u003c\/h2\u003e\n\u003cp\u003eEnzymes are often combined with other gut and recovery supplements:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"\/en-pt\/collections\/spijsvertering-darmen\"\u003eDigestion \u0026amp; Gut\u003c\/a\u003e — \u003cem\u003efor probiotics, prebiotics and the gut theme\u003c\/em\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/en-pt\/collections\/levende-culturen\"\u003eLive cultures (probiotics)\u003c\/a\u003e — \u003cem\u003ecomplementary to digestive enzymes\u003c\/em\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/en-pt\/collections\/aminozuren\"\u003eAmino acids\u003c\/a\u003e — \u003cem\u003efor those who have difficulty breaking down protein\u003c\/em\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/en-pt\/collections\/hart-vaten\"\u003eHeart \u0026amp; Blood Vessels\u003c\/a\u003e — \u003cem\u003efor nattokinase and the cardiovascular theme\u003c\/em\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 id=\"bronnen\"\u003eSources \u0026amp; references\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eRegulation (EU) 432\/2012 — authorised health claim for lactase enzyme\u003c\/li\u003e\n\u003cli\u003eRoxas (2008) — Role of enzyme supplementation in digestive disorders (Altern Med Rev)\u003c\/li\u003e\n\u003cli\u003eMaurer (2001) — Bromelain: biochemistry, pharmacology and medical use (Cell Mol Life Sci)\u003c\/li\u003e\n\u003cli\u003eTian et al. (2024) — Nattokinase clinical applications review\u003c\/li\u003e\n\u003cli\u003eNetherlands Nutrition Centre (Voedingscentrum) — food digestion and enzymes\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eDisclaimer:\u003c\/strong\u003e This text is for informational purposes only and does not replace medical advice. Food supplements are not a substitute for a varied, balanced diet and a healthy lifestyle. If in doubt, always consult your doctor or an orthomolecular therapist.\u003c\/p\u003e","products":[{"product_id":"arthur-andrew-neprinol-afd-150-caps","title":"Neprinol AFD® – Enzyme Complex – 150 capsules","description":"\u003cp\u003eEnzyme complex with nattokinase and serrapeptase. Neprinol AFD® by Arthur Andrew Medical combines nattokinase (15,000 FU), serrapeptase (45,000 SPU) and a broad enzyme complex (papain, bromelain, lipase, proteases) with coenzyme Q10, amla extract and rutin. Plant-based Acid Armor capsules — acid-resistant without phthalates. Non-GMO, vegetarian, Kosher. 150 capsules, enough for 50–75 daily doses.\u003c\/p\u003e","brand":"Arthur Andrew Medical","offers":[{"title":"Default Title","offer_id":56767386026329,"sku":"AAM1071","price":82.95,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0941\/6127\/3177\/files\/Neprinol150caps.webp?v=1783521833"},{"product_id":"arthur-andrew-neprinol-afd-300-caps","title":"Neprinol AFD® – Enzyme Complex – 300 capsules","description":"\u003cp\u003eNeprinol AFD® combines nattokinase (15,000 FU), serrapeptase (45,000 SPU), proteinases, papain, bromelain and lipase — supplemented with magnesium, amla extract, rutin and coenzyme Q10. Packed in acid-resistant Acid Armor capsules made from plant cellulose, without phthalates. Non-GMO, Kosher, vegetarian. 300 capsules per pack.\u003c\/p\u003e","brand":"Arthur Andrew Medical","offers":[{"title":"Default Title","offer_id":56767386845529,"sku":"AAM1070","price":144.95,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0941\/6127\/3177\/files\/AAMNeprinol300_ec7cb2f6-97d1-4a55-9f4c-7567b2cef98b.webp?v=1783581906"},{"product_id":"arthur-andrew-serretia-180-caps","title":"Serretia® – Serrapeptase 250,000 SPU – 180 capsules","description":"\u003cp\u003ePure serrapeptase — without additives. Arthur Andrew Medical Serretia® contains 250,000 SPU serrapeptase per dose (2 capsules), packed in plant-based Acid Armor capsules that protect the enzymes from stomach acid. Vegetarian (AVA), Kosher (Star-K), Non-GMO. 180 capsules, enough for 90 doses.\u003c\/p\u003e","brand":"Arthur Andrew Medical","offers":[{"title":"Default Title","offer_id":56767388746073,"sku":"AAM1120","price":104.95,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0941\/6127\/3177\/files\/Serretia180AAM.webp?v=1783519879"},{"product_id":"arthur-andrew-serretia-90-caps","title":"Serrétia® – 90 capsules","description":"\u003cp\u003eSerrétia® is a pure serrapeptase supplement by Arthur Andrew Medical — 125,000 SPU per capsule (250,000 SPU per 2 capsules) in an Acid Armor capsule that protects enzymes from stomach acid. The pack contains 90 plant-based capsules, enough for 45 to 90 doses.\u003c\/p\u003e","brand":"Arthur Andrew Medical","offers":[{"title":"Default Title","offer_id":56767389827417,"sku":"AAM1121","price":52.95,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0941\/6127\/3177\/files\/AAMSerretia90.webp?v=1783520095"},{"product_id":"arthur-andrew-syntol-amd-360-caps","title":"Syntol AMD® – 360 capsules","description":"\u003cp\u003eLive cultures, fibre and enzymes in one formula. Syntol AMD by Arthur Andrew Medical combines 13.6 billion CFU of spore-forming and lactic acid-producing microorganisms with dietary fibre (isomalto-oligosaccharide) and an enzyme complex (including serrapeptase, amylase, cellulase). Plant-based Acid Armor capsules protect the contents from stomach acid. Free from gluten, soy and dairy. 360 capsules, enough for approx. 90 daily doses.\u003c\/p\u003e","brand":"Arthur Andrew Medical","offers":[{"title":"Default Title","offer_id":56767408046425,"sku":"AAM1140","price":124.95,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0941\/6127\/3177\/files\/AAMSyntol.webp?v=1783523118"},{"product_id":"arthur-andrew-neprinol-afd-90-caps","title":"Neprinol AFD® – Enzyme Complex – 90 capsules","description":"\u003cp\u003eNeprinol AFD® is an enzyme complex in capsules with nattokinase, serrapeptase, proteinases, papain, bromelain, and lipase, supplemented with magnesium, amla extract, rutin, and coenzyme Q10. The formula is available in acid-resistant Acid Armor capsules made of vegetable cellulose, without coating.\u003c\/p\u003e\n\u003cp\u003eAcid Armor Capsule • 90 capsules per package • Non-GMO • Kosher • Vegetarian\u003c\/p\u003e","brand":"Arthur Andrew Medical","offers":[{"title":"Default Title","offer_id":56767412240729,"sku":"AAM1073","price":57.95,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0941\/6127\/3177\/files\/AAMNeprinol90_f0116be4-2933-412c-a815-e82db38fdcc9.webp?v=1783520748"},{"product_id":"arthur-andrew-devigest-ads-180-caps","title":"Devigest ADS® – Enzyme Formula – 180 capsules","description":"\u003cp\u003eA broad spectrum of digestive enzymes in one formula. Devigest ADS® by Arthur Andrew Medical combines peptidase DPP-IV, lactase (2,000 ALU), alpha-galactosidase and an extensive enzyme complex (including bromelain, lipase and papain). Plant-based capsules, free from gluten, soy and dairy. 180 capsules, enough for 90 servings.\u003c\/p\u003e","brand":"Arthur Andrew Medical","offers":[{"title":"Default Title","offer_id":56767413518681,"sku":"AAM1010","price":50.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0941\/6127\/3177\/files\/Devigest_7e278132-1701-4730-bdcc-e96d0772e09c.webp?v=1784278464"},{"product_id":"arthur-andrew-nattovena-180-caps","title":"Nattovéna® (Nattokinase) – 180 capsules","description":"\u003cp\u003eNattovena® by Arthur Andrew Medical contains 4,000 FU (fibrinolytic units) of nattokinase per capsule. The product consists of a single active ingredient in a plant-based cellulose capsule. To be taken on an empty stomach.\u003c\/p\u003e","brand":"Arthur Andrew Medical","offers":[{"title":"Default Title","offer_id":56767419777369,"sku":"AAM1060","price":50.95,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0941\/6127\/3177\/files\/Nattovena180.png?v=1783585934"},{"product_id":"arthur-andrew-nattovena-90-caps","title":"Nattovéna® (Nattokinase) – 90 capsules","description":"\u003cp\u003eNattovena® by Arthur Andrew Medical contains 4,000 FU (fibrinolytic units) of nattokinase per capsule. The product consists of a single active ingredient in a plant-based cellulose capsule. To be taken on an empty stomach.\u003c\/p\u003e","brand":"Arthur Andrew Medical","offers":[{"title":"Default Title","offer_id":56767420498265,"sku":"AAM1061","price":30.95,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0941\/6127\/3177\/files\/Nattovena90.png?v=1783585774"},{"product_id":"arthur-andrew-fibrovera-ahs-90-cap","title":"Fibrovera AHS® – 90 capsules","description":"\u003cp\u003eFibrovera® AHS combines an enzyme blend (serrapeptase, nattokinase NSK®, bromelain) with a herbal blend (GLA, DIM, 5-HTP, black cohosh, dong quai) and 50 mg vitamin B6 per capsule — developed by Arthur Andrew Medical. The jar contains 90 capsules, enough for 30 to 90 doses depending on intake.\u003c\/p\u003e","brand":"Arthur Andrew Medical","offers":[{"title":"Default Title","offer_id":56768708116825,"sku":"AAM1040","price":69.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0941\/6127\/3177\/files\/Fibrovera.webp?v=1783589042"},{"product_id":"arthur-andrew-aminolase-tpa-90-caps","title":"Aminolase TPA® – 90 capsules","description":"\u003cp\u003eAminolase® TPA is an acid-stable protease enzyme complex by Arthur Andrew Medical, specifically formulated for use with protein-rich meals and protein shakes. Each capsule contains 250 mg Acid Stable Protease Blend in a plant-based cellulose capsule — the jar contains 90 capsules.\u003c\/p\u003e","brand":"Arthur Andrew Medical","offers":[{"title":"Default Title","offer_id":56768772866393,"sku":"AAM1000","price":49.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0941\/6127\/3177\/files\/Aminolase.webp?v=1783585554"},{"product_id":"arthur-andrew-floraphage-90-caps","title":"Floraphage – 90 capsules – bacteriophage","description":"\u003cp\u003eFloraphage by Arthur Andrew is a food supplement in capsule form, built around a bacteriophage. Each capsule provides a fixed amount of this ingredient, packed in a plant-based capsule made of hydroxypropyl methylcellulose. The formula is supplemented with non-GMO rice dextrin. Arthur Andrew is known for supplements with less common ingredients. Floraphage is intended to supplement a varied diet, not to replace it.\u003c\/p\u003e","brand":"Arthur Andrew Medical","offers":[{"title":"Default Title","offer_id":56768862912857,"sku":"AAM1050","price":54.95,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0941\/6127\/3177\/files\/Floraphage.webp?v=1783586936"},{"product_id":"aam-neprofin-avf-1kg","title":"Neprofin AVF® - 1 kg","description":"\u003cp\u003e\u003cstrong\u003eLAST FEW ITEMS - WILL NOT BE RESTOCKED\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eArthur Andrew Neprofin AVF is an enzyme complex in powder form, developed for horses, dogs and other animals. It contains proteases, amylases and lipases, among others, and is mixed into the feed daily.\u003c\/p\u003e","brand":"Arthur Andrew Medical","offers":[{"title":"Default Title","offer_id":56768956367193,"sku":"AAM1100","price":175.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0941\/6127\/3177\/files\/aam-neprofin-avf-1kg-1.jpg?v=1773917754"},{"product_id":"arthur-andrew-novequin-dpf-1-kg","title":"Novequin DPF® - 1 kg","description":"\u003cp\u003e\u003cstrong\u003eLAST FEW ITEMS - WILL NOT BE RESTOCKED\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWhat is Novequin DPF? 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Everything comes in one plant-based capsule of about 450 mg enzyme blend. The jar of 90 capsules lasts 30 days at one capsule per meal.\u003c\/span\u003e\u003cbr\u003e\u003c\/p\u003e","brand":"Doctor's Best","offers":[{"title":"Default Title","offer_id":56769254588761,"sku":"9249","price":30.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0941\/6127\/3177\/files\/DrBestDigestiveenymen_88c2166c-559c-4ccb-9ed0-f73212364833.webp?v=1783515313"},{"product_id":"doctors-best-digestive-health-probiotic-2-billion-60-caps","title":"Digestive Health Enzymes – 60 capsules","description":"\u003cp\u003e\u003cspan\u003eDoctor's Best Digestive Health Enzymes is a broad-spectrum formula with sixteen digestive enzymes — targeting the breakdown of carbohydrates, fibre, proteins and fats. Supplemented with Bacillus subtilis as a live culture. A formula in a smaller starter jar, for anyone who wants to try this enzyme formula first. Jar of 60 capsules, enough for about three weeks at one capsule per meal.\u003c\/span\u003e\u003c\/p\u003e","brand":"Doctor's Best","offers":[{"title":"Default Title","offer_id":56769286963545,"sku":"9375","price":20.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0941\/6127\/3177\/files\/DrBestProbiotica_28b729e1-93f5-4e14-b13f-86f1aa4b93ef.webp?v=1783505328"},{"product_id":"doctors-best-betaine-hcl-pepsin-gentian-bitters-120-caps","title":"Betaine HCl Pepsin \u0026 Gentian Bitters – 120 capsules","description":"\u003cp\u003eDoctor’s Best Betaine HCl Pepsin \u0026amp; Gentian combines betaine hydrochloride, pepsin and gentian root powder (Gentiana lutea) in one capsule — a traditional combination for protein-rich meals. Pepsin is a protein-splitting enzyme that occurs naturally in the stomach; gentian is a European bitter plant that has been used in cooking for centuries. 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