{"title":"Lumbrokinase","description":"\u003cp\u003e\u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"BreadcrumbList\",\n  \"itemListElement\": [\n    { \"@type\": \"ListItem\", \"position\": 1, \"name\": \"Home\", \"item\": \"https:\/\/plenthera.com\/\" },\n    { \"@type\": \"ListItem\", \"position\": 2, \"name\": \"Categorieën\", \"item\": \"https:\/\/plenthera.com\/collections\/\" },\n    { \"@type\": \"ListItem\", \"position\": 3, \"name\": \"Lumbrokinase\", \"item\": \"https:\/\/plenthera.com\/collections\/lumbrokinase\/\" }\n  ]\n}\n\u003c\/script\u003e \u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"CollectionPage\",\n  \"name\": \"Lumbrokinase bij Plenthera\",\n  \"description\": \"Premium lumbrokinase en nattokinase — fibrinolytische enzymen voor cardiovasculair onderzoek.\",\n  \"url\": \"https:\/\/plenthera.com\/collections\/lumbrokinase\/\",\n  \"inLanguage\": \"nl-NL\",\n  \"isPartOf\": { \"@type\": \"WebSite\", \"name\": \"Plenthera\", \"url\": \"https:\/\/plenthera.com\/\" },\n  \"about\": { \"@type\": \"Thing\", \"name\": \"Lumbrokinase\", \"description\": \"Lumbrokinase is een fibrinolytisch enzym uit aardwormen, gebruikt in cardiovasculaire context.\" }\n}\n\u003c\/script\u003e \u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"FAQPage\",\n  \"mainEntity\": [\n    {\"@type\":\"Question\",\"name\":\"Wat is nattokinase?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Fibrinolytisch enzym uit Japanse natto (gefermenteerde sojaboon door Bacillus subtilis natto). Onderzocht in cardiovasculair context.\"}},\n    {\"@type\":\"Question\",\"name\":\"Mag nattokinase met bloedverdunners?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"NIET zonder medisch overleg. Nattokinase werkt fibrinolytisch — combineren met bloedverdunners (warfarine, NOACs, aspirine) verhoogt bloedingsrisico.\"}},\n    {\"@type\":\"Question\",\"name\":\"Hoeveel nattokinase per dag?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"100-200 mg per dag, 2.000-4.000 FU. Volg etiket en overleg met arts bij medische context.\"}}\n  ]\n}\n\u003c\/script\u003e\u003c\/p\u003e\n\u003carticle\u003e\n\u003cp\u003e\u003cem\u003eWritten by the Plenthera team (orthomolecularly trained). Scientifically reviewed in April 2026. Last updated: April 30, 2026.\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eLumbrokinase is a fibrinolytic enzyme from earthworms — used in Traditional Chinese Medicine for centuries, now isolated and standardized. It is the most potent natural fibrinolytic enzyme per milligram. At Plenthera, you will find premium \u003ca href=\"\/en\/collections\/lumbrokinase\"\u003elumbrokinase\u003c\/a\u003e for those seeking maximum fibrinolytic action. With the same caution as nattokinase: always consult a doctor if you are using blood thinners.\u003c\/p\u003e\n\u003cnav aria-label=\"Table of Contents\"\u003e\n\u003ch2\u003eTable of Contents\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003e\u003ca href=\"#vergelijking\"\u003eLumbrokinase vs Nattokinase\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"#wat-is-lumbrokinase\"\u003eWhat is Lumbrokinase?\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"#wetenschap\"\u003eScience, Fibrinolysis and EFSA Status\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"#vormen\"\u003eThe Lumbrokinase forms at Plenthera\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"#hoe-gebruik\"\u003eHow to use lumbrokinase?\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"#mythes\"\u003eMyths and misunderstandings about lumbrokinase\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"#combineren\"\u003eCombining Lumbrokinase with other supplements\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"#faq\"\u003eFrequently Asked Questions\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"#bronnen\"\u003eSources\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003c\/nav\u003e\n\u003csection\u003e\n\u003ch2 id=\"vergelijking\"\u003eLumbrokinase vs Nattokinase\u003c\/h2\u003e\n\u003ctable\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eAspect\u003c\/th\u003e\n\u003cth\u003eLumbrokinase\u003c\/th\u003e\n\u003cth\u003eNattokinase\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eSource\u003c\/td\u003e\n\u003ctd\u003eEarthworms\u003c\/td\u003e\n\u003ctd\u003eJapanese natto fermentation\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePotency per mg\u003c\/td\u003e\n\u003ctd\u003eHigher\u003c\/td\u003e\n\u003ctd\u003eStandard\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePrice\u003c\/td\u003e\n\u003ctd\u003ePremium\u003c\/td\u003e\n\u003ctd\u003eStandard\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eVegan\u003c\/td\u003e\n\u003ctd\u003eNo — animal-derived\u003c\/td\u003e\n\u003ctd\u003eYes — soy fermentation\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eClinical research\u003c\/td\u003e\n\u003ctd\u003eMore limited\u003c\/td\u003e\n\u003ctd\u003eMore extensive\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/section\u003e\n\u003csection\u003e\n\u003ch2 id=\"wat-is-lumbrokinase\"\u003eWhat is lumbrokinase?\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eLumbrokinase is a fibrinolytic enzyme mixture from earthworms (especially Lumbricus rubellus and Eisenia fetida). It has been used for centuries in Traditional Chinese Medicine (Di Long), and is now modernly standardized for cardiovascular applications.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eLumbrokinase was isolated from earthworms in China in the 1990s — a traditional TCM ingredient called Di Long. Science shows that earthworms have a complex fibrinolytic enzyme system, presumably evolved to break down blood clots from prey.\u003c\/p\u003e\n\u003cp\u003eCompared to nattokinase, lumbrokinase is more potent per milligram, but is produced by fewer manufacturers — and is therefore more expensive. The premium brand is Boluoke (Canadian, standardized for activity). For those who want maximum fibrinolytic action — under medical consultation — lumbrokinase is the premium choice over nattokinase.\u003c\/p\u003e\n\u003cp\u003eThe same caution as with nattokinase applies: if you are taking blood thinners, before surgery, or if you have clotting disorders, DO NOT use without a doctor's consultation. See our \u003ca href=\"https:\/\/www.nvwa.nl\/onderwerpen\/voedingssupplementen\/risico-s-voedingssupplementen\" rel=\"noopener noreferrer\" target=\"_blank\"\u003eNVWA\u003c\/a\u003e guideline for supplementation with medication use.\u003c\/p\u003e\n\u003c\/section\u003e\n\u003csection\u003e\n\u003ch2 id=\"wetenschap\"\u003eScience, fibrinolysis and EFSA status\u003c\/h2\u003e\n\u003cp\u003eScientific research into nattokinase focuses on cardiovascular applications — fibrinolysis, blood pressure, fibrinogen levels, vascular function. Clinical research in humans shows positive results in small-scale studies, often with dosages of 100-200 mg per day.\u003c\/p\u003e\n\u003cp\u003eImportant: there are NO health claims for nattokinase recognized by \u003ca href=\"https:\/\/www.efsa.europa.eu\/en\/topics\/topic\/health-claims\" rel=\"noopener noreferrer\" target=\"_blank\"\u003eEFSA\u003c\/a\u003e. We therefore do not make literal claims about its effects. Nattokinase is a food supplement, not a medicine.\u003c\/p\u003e\n\u003cp\u003eCRUCIAL: if you are using blood thinners (warfarin, NOACs, aspirin), before surgery (avoid 2 weeks prior), if you have clotting disorders or bleeding diathesis: DO NOT use without medical consultation.\u003c\/p\u003e\n\u003c\/section\u003e\n\u003csection\u003e\n\u003ch2 id=\"vormen\"\u003eThe lumbrokinase forms at Plenthera\u003c\/h2\u003e\n\u003ch3\u003eLumbrokinase 20-40 mg capsules\u003c\/h3\u003e\n\u003cp\u003eStandard premium dosage.\u003c\/p\u003e\n\u003ch3\u003eBoluoke (premium brand)\u003c\/h3\u003e\n\u003cp\u003eCanadian standardized formula.\u003c\/p\u003e\n\u003ch3\u003eLumbrokinase + nattokinase\u003c\/h3\u003e\n\u003cp\u003ePremium combination of two fibrinolytics.\u003c\/p\u003e\n\u003c\/section\u003e\n\u003csection\u003e\n\u003ch2 id=\"hoe-gebruik\"\u003eHow to use lumbrokinase?\u003c\/h2\u003e\n\u003cp\u003eSimple basic approach for lumbrokinase\/nattokinase:\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003eTake between meals for maximum systemic effect.\u003c\/li\u003e\n\u003cli\u003eStandard 100-200 mg\/day (2,000-4,000 FU).\u003c\/li\u003e\n\u003cli\u003eWhen using blood thinners: consult a doctor beforehand.\u003c\/li\u003e\n\u003cli\u003eBefore surgery: stop at least 2 weeks prior.\u003c\/li\u003e\n\u003cli\u003eIn case of doubt or medical context: consult a doctor.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003c\/section\u003e\n\u003csection\u003e\n\u003ch2 id=\"mythes\"\u003eMyths and misunderstandings about lumbrokinase\u003c\/h2\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eMyth 1: \"Nattokinase is a natural aspirin.\"\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eHalf true — both have fibrinolytic \/ antithrombotic effects, but different mechanisms. Nattokinase is not a substitute for aspirin in a medical context.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eMyth 2: \"Everyone can safely take nattokinase.\"\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eIncorrect. With blood thinners, before surgery, during pregnancy or with bleeding diathesis: avoid or consult a doctor.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eMyth 3: \"The more nattokinase, the better the cardiovascular effect.\"\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eNo additional effect has been demonstrated above 4,000 FU\/day, and the bleeding risk increases.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eMyth 4: \"Eating fresh natto provides enough nattokinase.\"\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eFor a wholefood approach: yes, partly. For a systemic clinical effect: the dosage from food is usually too low — supplements are more effective.\u003c\/p\u003e\n\u003c\/section\u003e\n\u003csection\u003e\n\u003ch2 id=\"combineren\"\u003eCombining Lumbrokinase with other supplements\u003c\/h2\u003e\n\u003cp\u003eNattokinase is often combined for cardiovascular issues. Popular combinations:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/omega-3-vetzuren\"\u003eOmega 3\u003c\/a\u003e: cardiovascular cluster with EFSA claim.\u003c\/li\u003e\n\u003cli\u003eQ10: mitochondrial and cardio.\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/magnesium\"\u003eMagnesium\u003c\/a\u003e: cardio mineral.\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/kurkuma\"\u003eTurmeric\u003c\/a\u003e: inflammation modulation.\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/vitamine-k\"\u003eVitamin K2\u003c\/a\u003e: relevant — affects clotting, in a different direction than nattokinase. Discuss with a doctor.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/section\u003e\n\u003csection\u003e\n\u003ch2 id=\"faq\"\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eWhat is nattokinase?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFibrinolytic enzyme from Japanese natto.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHow does nattokinase work?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBreaks down fibrin (blood clot protein), supports natural fibrinolysis.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHow much nattokinase per day?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e100-200 mg, 2,000-4,000 FU.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhen to take nattokinase?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBetween meals for systemic effect.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCan nattokinase be taken with blood thinners?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNOT without medical consultation — bleeding risk.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhat is FU in nattokinase?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFibrinolytic Units — unit for fibrinolytic activity.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNattokinase for circulation?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eClinically studied. EFSA claim not recognized.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDifference between nattokinase and aspirin?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eDifferent mechanisms — not interchangeable in a medical context.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDoes nattokinase have side effects?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePossible: bleeding tendency at high doses, especially with other antithrombotics.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVegan nattokinase?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eYes — from soy fermentation, plant-based.\u003c\/p\u003e\n\u003c\/section\u003e\n\u003csection\u003e\n\u003ch2 id=\"bronnen\"\u003eSources\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.efsa.europa.eu\/en\/topics\/topic\/health-claims\" rel=\"noopener noreferrer\" target=\"_blank\"\u003eEFSA Regulation (EU) 432\/2012\u003c\/a\u003e — no overarching enzyme claims; individual claims limited.\u003c\/li\u003e\n\u003cli\u003eSumi H. et al., \"A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto\", Experientia (1987).\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30013308\/\" rel=\"noopener noreferrer\" target=\"_blank\"\u003eChen H. et al.\u003c\/a\u003e, \"Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases\", Biomark Insights (2018).\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/section\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eDisclaimer:\u003c\/strong\u003e This text is for informational purposes only and does not replace medical advice. Lumbrokinase is a food supplement, not a medicine. In case of doubt or if you are using medication, we recommend consulting a doctor or orthomolecular therapist first.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/article\u003e","products":[{"product_id":"doctors-best-lumbrokinase-20mg-60-vcaps","title":"Lumbrokinase 20 mg – 60 vcaps","description":"\u003cp\u003e\u003cmeta charset=\"utf-8\"\u003e\u003cspan\u003eDoctor's Best Lumbrokinase delivers a standardized enzyme extract from the earthworm Lumbricus rubellus, traditionally used in East Asian food tradition. The raw material is obtained through a purification process — only the enzyme complex, no worm parts. For those seeking a proteolytic enzyme from a traditional Eastern source. Jar of 60 vegetarian capsules, sufficient for 30 days at two capsules per day.\u003c\/span\u003e\u003c\/p\u003e","brand":"Doctor's Best","offers":[{"title":"Default Title","offer_id":56769453654361,"sku":"9288","price":59.95,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0941\/6127\/3177\/files\/doctor-s-best-lumbrokinase-60-v-caps-20mg-1.jpg?v=1773933599"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0941\/6127\/3177\/collections\/doctor-s-best-lumbrokinase-60-v-caps-20mg-3.jpg?v=1776088097","url":"https:\/\/www.plenthera.com\/en\/collections\/lumbrokinase.oembed","provider":"Plenthera","version":"1.0","type":"link"}