{"title":"Nattokinase","description":"\u003cp\u003e\u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"BreadcrumbList\",\n  \"itemListElement\": [\n    { \"@type\": \"ListItem\", \"position\": 1, \"name\": \"Home\", \"item\": \"https:\/\/plenthera.com\/\" },\n    { \"@type\": \"ListItem\", \"position\": 2, \"name\": \"Categorieën\", \"item\": \"https:\/\/plenthera.com\/collections\/\" },\n    { \"@type\": \"ListItem\", \"position\": 3, \"name\": \"Nattokinase\", \"item\": \"https:\/\/plenthera.com\/collections\/nattokinase\/\" }\n  ]\n}\n\u003c\/script\u003e \u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"CollectionPage\",\n  \"name\": \"Nattokinase bij Plenthera\",\n  \"description\": \"Premium nattokinase uit Japanse natto. Fibrinolytisch enzym voor cardiovasculair onderzoek.\",\n  \"url\": \"https:\/\/plenthera.com\/collections\/nattokinase\/\",\n  \"inLanguage\": \"nl-NL\",\n  \"isPartOf\": { \"@type\": \"WebSite\", \"name\": \"Plenthera\", \"url\": \"https:\/\/plenthera.com\/\" },\n  \"about\": { \"@type\": \"Thing\", \"name\": \"Nattokinase\", \"description\": \"Nattokinase is een fibrinolytisch enzym uit Japanse natto-fermentatie.\" }\n}\n\u003c\/script\u003e \u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"FAQPage\",\n  \"mainEntity\": [\n    {\"@type\":\"Question\",\"name\":\"Wat is nattokinase?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Fibrinolytisch enzym uit Japanse natto (gefermenteerde sojaboon door Bacillus subtilis natto). Onderzocht in cardiovasculair context.\"}},\n    {\"@type\":\"Question\",\"name\":\"Mag nattokinase met bloedverdunners?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"NIET zonder medisch overleg. Nattokinase werkt fibrinolytisch — combineren met bloedverdunners (warfarine, NOACs, aspirine) verhoogt bloedingsrisico.\"}},\n    {\"@type\":\"Question\",\"name\":\"Hoeveel nattokinase per dag?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"100-200 mg per dag, 2.000-4.000 FU. Volg etiket en overleg met arts bij medische context.\"}}\n  ]\n}\n\u003c\/script\u003e\u003c\/p\u003e\n\u003carticle\u003e\n\u003cp\u003e\u003cem\u003eWritten by the Plenthera team (orthomolecularly trained). Scientifically reviewed in April 2026. Last updated: April 30, 2026.\u003c\/em\u003e\u003c\/p\u003e\n\n\u003cp\u003eNattokinase is perhaps the most remarkable enzyme in this category — a fibrinolytic enzyme from fermented soybean that can break down fibrin (blood clot protein). It was isolated in Japan in 1980 from natto, a traditional breakfast dish. At Plenthera, you'll find premium \u003ca href=\"\/en\/collections\/nattokinase\"\u003enattokinase\u003c\/a\u003e in capsules with a standardized 2,000+ FU per serving. CRUCIAL NOTE: always consult a doctor beforehand if using blood thinners or before surgery.\u003c\/p\u003e\n\n\u003cnav aria-label=\"Table of Contents\"\u003e\n\u003ch2\u003eTable of Contents\u003c\/h2\u003e\n\n\u003col\u003e\n\n\u003cli\u003e\u003ca href=\"#vergelijking\"\u003eWhich nattokinase is right for you?\u003c\/a\u003e\u003c\/li\u003e\n\n\u003cli\u003e\u003ca href=\"#wat-is-nattokinase\"\u003eWhat is nattokinase?\u003c\/a\u003e\u003c\/li\u003e\n\n\u003cli\u003e\u003ca href=\"#wetenschap\"\u003eScience, fibrinolysis, and EFSA status\u003c\/a\u003e\u003c\/li\u003e\n\n\u003cli\u003e\u003ca href=\"#vormen\"\u003eThe nattokinase forms at Plenthera\u003c\/a\u003e\u003c\/li\u003e\n\n\u003cli\u003e\u003ca href=\"#hoe-gebruik\"\u003eHow to use nattokinase?\u003c\/a\u003e\u003c\/li\u003e\n\n\u003cli\u003e\u003ca href=\"#mythes\"\u003eMyths and misconceptions about nattokinase\u003c\/a\u003e\u003c\/li\u003e\n\n\u003cli\u003e\u003ca href=\"#combineren\"\u003eCombining nattokinase with other supplements\u003c\/a\u003e\u003c\/li\u003e\n\n\u003cli\u003e\u003ca href=\"#faq\"\u003eFrequently asked questions\u003c\/a\u003e\u003c\/li\u003e\n\n\u003cli\u003e\u003ca href=\"#bronnen\"\u003eSources\u003c\/a\u003e\u003c\/li\u003e\n\n\n\u003c\/ol\u003e\n\n\u003c\/nav\u003e\n\u003csection\u003e\n\u003ch2 id=\"vergelijking\"\u003eWhich nattokinase is right for you?\u003c\/h2\u003e\n\n\u003ctable\u003e\n\n\u003cthead\u003e\n\n\u003ctr\u003e\n\n\u003cth\u003eForm\u003c\/th\u003e\n\n\u003cth\u003eFU\u003c\/th\u003e\n\n\u003cth\u003eBest for\u003c\/th\u003e\n\n\n\u003c\/tr\u003e\n\n\n\u003c\/thead\u003e\n\n\u003ctbody\u003e\n\n\u003ctr\u003e\n\n\u003ctd\u003eCapsules 2000 FU\u003c\/td\u003e\n\n\u003ctd\u003eStandard\u003c\/td\u003e\n\n\u003ctd\u003eGeneral cardiovascular\u003c\/td\u003e\n\n\n\u003c\/tr\u003e\n\n\u003ctr\u003e\n\n\u003ctd\u003eCapsules 4000 FU\u003c\/td\u003e\n\n\u003ctd\u003eHigh\u003c\/td\u003e\n\n\u003ctd\u003eMaximum effect (consult with doctor)\u003c\/td\u003e\n\n\n\u003c\/tr\u003e\n\n\u003ctr\u003e\n\n\u003ctd\u003e+ serrapeptase\u003c\/td\u003e\n\n\u003ctd\u003eVariable\u003c\/td\u003e\n\n\u003ctd\u003ePremium fibrinolytic\u003c\/td\u003e\n\n\n\u003c\/tr\u003e\n\n\n\u003c\/tbody\u003e\n\n\n\u003c\/table\u003e\n\n\u003c\/section\u003e\n\u003csection\u003e\n\u003ch2 id=\"wat-is-nattokinase\"\u003eWhat is nattokinase?\u003c\/h2\u003e\n\n\u003cp\u003e\u003cstrong\u003eNattokinase is a fibrinolytic enzyme (fibrin-degrading) extracted from Japanese natto — fermented soybean by Bacillus subtilis natto. It was discovered in 1980 by Dr. Hiroyuki Sumi and has since been clinically studied for cardiovascular applications.\u003c\/strong\u003e\u003c\/p\u003e\n\n\u003cp\u003eNatto is a Japanese breakfast dish with a distinctive taste, texture, and smell — made from fermented soybeans with the bacterium Bacillus subtilis natto. In 1980, Dr. Sumi isolated the enzyme nattokinase from this fermentation and demonstrated its fibrinolytic action — fibrin (the protein component of blood clots) was broken down in vitro. Since then, nattokinase has been extensively researched for cardiovascular applications.\u003c\/p\u003e\n\n\u003cp\u003eIn clinical research, nattokinase has been studied for blood pressure, fibrinogen levels, vascular function, and general cardiovascular support. Results have been positive in multiple studies, but EFSA has not recognized any claims. The main practical note: nattokinase affects the clotting system — therefore, medical caution is essential.\u003c\/p\u003e\n\n\u003cp\u003eFor those who want to approach cardiovascular research more broadly — in addition to omega 3, Q10, turmeric — nattokinase can be a logical addition. But only in consultation with a doctor if there are clotting disorders or if blood thinners are being used. See our \u003ca href=\"\/en\/collections\/omega-3-vetzuren\"\u003eomega 3 category\u003c\/a\u003e and our \u003ca href=\"\/en\/collections\/kurkuma\"\u003eturmeric category\u003c\/a\u003e for related cardiovascular research categories.\u003c\/p\u003e\n\n\u003c\/section\u003e\n\u003csection\u003e\n\u003ch2 id=\"wetenschap\"\u003eScience, fibrinolysis, and EFSA status\u003c\/h2\u003e\n\n\u003cp\u003eScientific research into nattokinase focuses on cardiovascular applications — fibrinolysis, blood pressure, fibrinogen levels, vascular function. Clinical research in humans shows positive results in small-scale studies, often with dosages of 100-200 mg per day.\u003c\/p\u003e\n\n\u003cp\u003eImportant: there are NO health claims recognized by \u003ca rel=\"noopener noreferrer\" href=\"https:\/\/www.efsa.europa.eu\/en\/topics\/topic\/health-claims\" target=\"_blank\"\u003eEFSA\u003c\/a\u003e for nattokinase. We therefore make no literal efficacy claims. Nattokinase is a dietary supplement, not a medicine.\u003c\/p\u003e\n\n\u003cp\u003eCRUCIAL: if using blood thinners (warfarin, NOACs, aspirin), before surgery (avoid 2 weeks prior), with clotting disorders or bleeding diathesis: DO NOT use without medical consultation.\u003c\/p\u003e\n\n\u003c\/section\u003e\n\u003csection\u003e\n\u003ch2 id=\"vormen\"\u003eThe nattokinase forms at Plenthera\u003c\/h2\u003e\n\n\u003ch3\u003eNattokinase 2000 FU capsules\u003c\/h3\u003e\n\n\u003cp\u003eStandard dosage — 100 mg per capsule with 2,000 FU. For general cardiovascular research.\u003c\/p\u003e\n\n\u003ch3\u003eNattokinase 4000 FU capsules\u003c\/h3\u003e\n\n\u003cp\u003eHigher dosage — for those who want higher fibrinolytic activity. Premium price point.\u003c\/p\u003e\n\n\u003ch3\u003eNattokinase + serrapeptase\u003c\/h3\u003e\n\n\u003cp\u003eCombination of two fibrinolytic enzymes — premium niche.\u003c\/p\u003e\n\n\u003c\/section\u003e\n\u003csection\u003e\n\u003ch2 id=\"hoe-gebruik\"\u003eHow to use nattokinase?\u003c\/h2\u003e\n\n\u003cp\u003eSimple basic approach for nattokinase:\u003c\/p\u003e\n\n\u003col\u003e\n\n\u003cli\u003eTake between meals for maximum systemic effect.\u003c\/li\u003e\n\n\u003cli\u003eStandard 100-200 mg\/day (2,000-4,000 FU).\u003c\/li\u003e\n\n\u003cli\u003eIf using blood thinners: medical consultation beforehand.\u003c\/li\u003e\n\n\u003cli\u003eBefore surgery: stop at least 2 weeks prior.\u003c\/li\u003e\n\n\u003cli\u003eIn case of doubt or medical context: consult a doctor.\u003c\/li\u003e\n\n\n\u003c\/ol\u003e\n\n\u003c\/section\u003e\n\u003csection\u003e\n\u003ch2 id=\"mythes\"\u003eMyths and misconceptions about nattokinase\u003c\/h2\u003e\n\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eMyth 1: \"Nattokinase is a natural aspirin.\"\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\n\u003cp\u003eHalf true — both have fibrinolytic \/ antithrombotic effects, but different mechanisms. Nattokinase is not a substitute for aspirin in a medical context.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eMyth 2: \"Everyone can safely take nattokinase.\"\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\n\u003cp\u003eIncorrect. With blood thinners, before surgery, during pregnancy or with bleeding diathesis: avoid or seek medical consultation.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eMyth 3: \"The more nattokinase, the better the cardiovascular effect.\"\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\n\u003cp\u003eAbove 4,000 FU\/day, no additional effect has been demonstrated, and bleeding risk increases.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eMyth 4: \"Eating fresh natto provides enough nattokinase.\"\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\n\u003cp\u003eFor a wholefood route: yes, partly. For systemic clinical effect: dosage from food is usually too low — supplement is more effective.\u003c\/p\u003e\n\n\u003c\/section\u003e\n\u003csection\u003e\n\u003ch2 id=\"combineren\"\u003eCombining nattokinase with other supplements\u003c\/h2\u003e\n\n\u003cp\u003eNattokinase is often combined for cardiovascular issues. Commonly chosen combinations:\u003c\/p\u003e\n\n\u003cul\u003e\n\n\u003cli\u003e\n\n\u003ca href=\"\/en\/collections\/omega-3-vetzuren\"\u003eOmega 3\u003c\/a\u003e: cardiovascular cluster with EFSA claim.\u003c\/li\u003e\n\n\u003cli\u003eQ10: mitochondrial and cardio.\u003c\/li\u003e\n\n\u003cli\u003e\n\n\u003ca href=\"\/en\/collections\/magnesium\"\u003eMagnesium\u003c\/a\u003e: cardio-mineral.\u003c\/li\u003e\n\n\u003cli\u003e\n\n\u003ca href=\"\/en\/collections\/kurkuma\"\u003eTurmeric\u003c\/a\u003e: inflammation modulation.\u003c\/li\u003e\n\n\u003cli\u003e\n\n\u003ca href=\"\/en\/collections\/vitamine-k\"\u003eVitamin K2\u003c\/a\u003e: relevant — affects clotting, in a different direction than nattokinase. Best discussed with a doctor.\u003c\/li\u003e\n\n\n\u003c\/ul\u003e\n\n\u003c\/section\u003e\n\u003csection\u003e\n\u003ch2 id=\"faq\"\u003eFrequently asked questions\u003c\/h2\u003e\n\n\u003cp\u003e\u003cstrong\u003eWhat is nattokinase?\u003c\/strong\u003e\u003c\/p\u003e\n\n\u003cp\u003eFibrinolytic enzyme from Japanese natto.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eHow does nattokinase work?\u003c\/strong\u003e\u003c\/p\u003e\n\n\u003cp\u003eBreaks down fibrin (blood clot protein), supports natural fibrinolysis.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eHow much nattokinase per day?\u003c\/strong\u003e\u003c\/p\u003e\n\n\u003cp\u003e100-200 mg, 2,000-4,000 FU.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eWhen to take nattokinase?\u003c\/strong\u003e\u003c\/p\u003e\n\n\u003cp\u003eBetween meals for systemic effect.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eCan nattokinase be taken with blood thinners?\u003c\/strong\u003e\u003c\/p\u003e\n\n\u003cp\u003eNOT without medical consultation — bleeding risk.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eWhat is FU for nattokinase?\u003c\/strong\u003e\u003c\/p\u003e\n\n\u003cp\u003eFibrinolytic Units — unit for fibrinolytic activity.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eNattokinase for circulation?\u003c\/strong\u003e\u003c\/p\u003e\n\n\u003cp\u003eClinically studied. EFSA claim not recognized.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eDifference between nattokinase and aspirin?\u003c\/strong\u003e\u003c\/p\u003e\n\n\u003cp\u003eDifferent mechanisms — not interchangeable in a medical context.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eDoes nattokinase have side effects?\u003c\/strong\u003e\u003c\/p\u003e\n\n\u003cp\u003ePossible: bleeding tendency with high dosages, especially with other antithrombotics.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eVegan nattokinase?\u003c\/strong\u003e\u003c\/p\u003e\n\n\u003cp\u003eYes — from soybean fermentation, plant-based.\u003c\/p\u003e\n\n\u003c\/section\u003e\n\u003csection\u003e\n\u003ch2 id=\"bronnen\"\u003eSources\u003c\/h2\u003e\n\n\u003cul\u003e\n\n\u003cli\u003e\n\n\u003ca rel=\"noopener noreferrer\" href=\"https:\/\/www.efsa.europa.eu\/en\/topics\/topic\/health-claims\" target=\"_blank\"\u003eEFSA Regulation (EU) 432\/2012\u003c\/a\u003e — no overarching enzyme claims; individual claims limited.\u003c\/li\u003e\n\n\u003cli\u003eSumi H. et al., \"A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto\", Experientia (1987).\u003c\/li\u003e\n\n\u003cli\u003e\n\n\u003ca rel=\"noopener noreferrer\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30013308\/\" target=\"_blank\"\u003eChen H. et al.\u003c\/a\u003e, \"Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases\", Biomark Insights (2018).\u003c\/li\u003e\n\n\n\u003c\/ul\u003e\n\n\u003c\/section\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eDisclaimer:\u003c\/strong\u003e This text is intended for informational purposes only and does not replace medical advice. Nattokinase is a dietary supplement, not a medicine. If in doubt or if taking medication, we recommend consulting a doctor or orthomolecular therapist first.\u003c\/em\u003e\u003c\/p\u003e\n\n\u003c\/article\u003e","products":[{"product_id":"arthur-andrew-neprinol-afd-150-caps","title":"Neprinol AFD® - 150 capsules","description":"\u003cp\u003eNeprinol AFD® is an enzyme complex in capsules with nattokinase, serrapeptase, proteinases, papain, bromelain and lipase, supplemented with magnesium, amla extract, rutin and coenzyme Q10. The formula is available in acid-resistant Acid Armor capsules made of vegetable cellulose, without coating.\u003c\/p\u003e\n\u003cp\u003eAcid Armor Capsule • 150 capsules per package • Non-GMO • Kosher • Vegetarian\u003c\/p\u003e","brand":"Arthur Andrew Medical","offers":[{"title":"Default Title","offer_id":56767386026329,"sku":"AAM1071","price":79.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0941\/6127\/3177\/files\/aam-neprinol-150-capsules-1.jpg?v=1773917372"},{"product_id":"arthur-andrew-neprinol-afd-300-caps","title":"Neprinol AFD® Enzyme Complex — 300 Capsules","description":"\u003cp\u003eNeprinol AFD® is an enzyme complex in capsules with nattokinase, serrapeptase, proteinases, papain, bromelain, and lipase, supplemented with magnesium, amla extract, rutin, and coenzyme Q10. The formula is available in acid-resistant Acid Armor capsules made of vegetable cellulose, without coating.\u003c\/p\u003e\n\u003cp\u003eAcid Armor Capsule • 300 capsules per package • Non-GMO • Kosher • Vegetarian\u003c\/p\u003e","brand":"Arthur Andrew Medical","offers":[{"title":"Default Title","offer_id":56767386845529,"sku":"AAM1070","price":139.95,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0941\/6127\/3177\/files\/aam-neprinol-300-capsules.jpg?v=1773917446"},{"product_id":"arthur-andrew-neprinol-afd-90-caps","title":"Neprinol AFD – 90 capsules | Advanced enzyme formula with nattokinase, serrapeptase, bromelain and papain - Arthur Andrew","description":"\u003cp\u003eNeprinol AFD® is an enzyme complex in capsules with nattokinase, serrapeptase, proteinases, papain, bromelain, and lipase, supplemented with magnesium, amla extract, rutin, and coenzyme Q10. The formula is available in acid-resistant Acid Armor capsules made of vegetable cellulose, without coating.\u003c\/p\u003e\n\u003cp\u003eAcid Armor Capsule • 90 capsules per package • Non-GMO • Kosher • Vegetarian\u003c\/p\u003e","brand":"Arthur Andrew Medical","offers":[{"title":"Default Title","offer_id":56767412240729,"sku":"AAM1073","price":55.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0941\/6127\/3177\/files\/aam-neprinol-90-capsules-1.jpg?v=1773917218"},{"product_id":"arthur-andrew-nattovena-180-caps","title":"Nattokinase® - 180 Caps","description":"\u003cp\u003eNattovena® by Arthur Andrew Medical contains 4,000 FU (fibrinolytic units) of nattokinase per capsule. The product consists of a single active ingredient in a vegetable cellulose capsule. To be taken on an empty stomach.\u003c\/p\u003e\n\u003cp\u003eAvailable in 90 and 180 capsules — to be taken on an empty stomach.\u003c\/p\u003e","brand":"Arthur Andrew Medical","offers":[{"title":"Default Title","offer_id":56767419777369,"sku":"AAM1060","price":49.95,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0941\/6127\/3177\/files\/aam-nattovena-4-000-fu-cap-180-capsules-1.jpg?v=1773848781"},{"product_id":"arthur-andrew-nattovena-90-caps","title":"Nattokinase® - 90 caps","description":"\u003cp\u003eNattovena® from Arthur Andrew Medical contains 4,000 FU (fibrinolytic units) of nattokinase per capsule. The product consists of a single active ingredient in a vegetable cellulose capsule. To be taken on an empty stomach.\u003c\/p\u003e\n\u003cp\u003eAvailable in 90 and 180 capsules — to be taken on an empty stomach.\u003c\/p\u003e","brand":"Arthur Andrew Medical","offers":[{"title":"Default Title","offer_id":56767420498265,"sku":"AAM1061","price":29.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0941\/6127\/3177\/files\/arthur-andrew-medical-nattovena-90caps.jpg?v=1773237033"},{"product_id":"doctors-best-nattokinase-2-000-fu-90-vcaps","title":"Nattokinase — 90 V-Caps (2,000 FU)","description":"\u003cp\u003e\u003cmeta charset=\"utf-8\"\u003e\u003cspan\u003eDoctor's Best Nattokinase delivers nattokinase per capsule - a serine protease extracted from natto, the traditional Japanese fermented soybean product. An entry-level jar for those who want to try nattokinase for the first time or maintain a smaller supply. For those who want to consume the Japanese fermentation heritage in a standardized supplement form. 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