
Vitamin D, vitamin C and zinc and the normal function of your immune system
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Why these three—starting with vitamin D
Your immune system is a complex network of white blood cells, antibodies, signalling substances, mucous membranes and organs. For three nutrients, the EU has established that they contribute to the normal function of the immune system: vitamin D, vitamin C and zinc. That is why they are often mentioned together.
Source: EU Register on nutrition and health claims (Regulation (EU) 432/2012 — officially authorised health claims).
Vitamin D
Vitamin D is also called 'the sunshine vitamin', because your skin produces it under the influence of sunlight. Vitamin D contributes to the normal function of the immune system.
In the Netherlands, the sun is too weak from about October to April for sufficient production of your own. The Dutch Health Council therefore advises several groups to take a vitamin D supplement, and some groups (such as people with dark skin, people who rarely go outside and people over 70) all year round. This is the Dutch advice; recommendations may differ in other countries.
How much vitamin D?
The Dutch Health Council advises most adults who need extra vitamin D to take 10 micrograms a day, and people over 70 20 micrograms a day. EFSA sets a tolerable upper level of 100 micrograms a day for adults, from all sources combined. Follow the recommended daily dose on the label.
Vitamin C and zinc
Vitamin C is water-soluble and is not produced by the body itself; you get it from food or a supplement. Vitamin C contributes to the normal function of the immune system and to the protection of cells from oxidative stress.
How much vitamin C?
The reference intake (RI) for vitamin C is 80 mg a day. With vegetables and fruit you can usually reach that easily. Vitamin C also contributes to maintaining the normal function of the immune system during and after intense physical exercise; the beneficial effect is obtained with a daily intake of 200 mg in addition to the recommended daily intake. High doses can cause digestive discomfort in some people; follow the recommended daily dose on the label.
Which form?
Ascorbic acid is the most common form. Buffered forms (such as sodium ascorbate or Ester-C) are less acidic and some people with a sensitive stomach find them more comfortable. Plant-based vitamin C complexes, for example from acerola, contain other plant compounds besides vitamin C.
Zinc
Zinc is a mineral involved in hundreds of enzymatic reactions. Zinc contributes to the normal function of the immune system and to the protection of cells from oxidative stress.
How much zinc?
The reference intake (RI) for zinc is 10 mg a day. Depending on the amount of phytate in the diet, EFSA recommends about 7.5-12.7 mg a day for women and 9.4-16.3 mg for men. EFSA sets a tolerable upper level of 25 mg of zinc a day for adults, from all sources combined. Long-term high doses can disturb copper status. Always follow the recommended daily dose on the label.
Which form?
Commonly used forms are zinc bisglycinate, zinc citrate, zinc gluconate and zinc oxide. They differ in zinc content per gram and in price; the label shows how much zinc a product provides per daily dose.
Frequently asked questions about vitamin D, C and zinc
What does vitamin C do for your immune system?
What does vitamin C do for your immune system?
Vitamin C contributes to the normal function of the immune system and to the protection of cells from oxidative stress. Vitamin C is a nutrient, not a medicine.
What does zinc do for your immune system?
What does zinc do for your immune system?
Zinc contributes to the normal function of the immune system. Use zinc according to the recommended daily dose on the label and stay below the tolerable upper level of 25 mg a day from all sources combined; long-term high doses are not recommended.
Can I combine vitamin D, C, and zinc in one multivitamin?
Can I combine vitamin D, C, and zinc in one multivitamin?
Yes. Most multivitamins contain all three, usually in doses around the reference intake. If you also use separate supplements, add up the total daily intake and pay particular attention to the tolerable upper levels for vitamin D and zinc.
Can I give my child the same supplements?
Can I give my child the same supplements?
Different amounts apply to children. The Dutch Health Council advises children aged 0 to 4 to take 10 micrograms of vitamin D daily; after that it depends on risk factors. For vitamin C and zinc, special children's products are often more suitable in terms of dose. Do not give children adult supplements and, if in doubt, consult the child health clinic or your GP.
How long before winter should I start?
How long before winter should I start?
For vitamin D, follow the advice of the Dutch Health Council: for some groups all year round, for others mainly in the winter months. You also get vitamin C and zinc from your diet; you can use a supplement at any time according to the recommended daily dose.
Combining vitamin D, C and zinc
What to look out for when combining
Vitamin D, vitamin C and zinc each contribute to the normal function of the immune system. That is why they are often used together, for example in a multivitamin or as separate products.
What to look out for
- Vitamin D: follow the Dutch Health Council's advice for your age and situation and stay below the tolerable upper level of 100 micrograms a day.
- Vitamin C: the reference intake is 80 mg a day; follow the recommended daily dose on the label.
- Zinc: stay below the tolerable upper level of 25 mg a day, from all sources combined.
- Add it up: if you use a multivitamin and separate supplements, add up the total intake per nutrient.
Vitamin D, vitamin C and zinc are a logical trio: for all three, the EU has established that they contribute to the normal function of the immune system. A varied diet, enough sleep and exercise remain the foundation.
Disclaimer: This article is for information only and does not replace medical advice. A food supplement is not a substitute for a varied, balanced diet and a healthy lifestyle. If in doubt or if you take medication, consult a doctor or pharmacist. Do not exceed the recommended daily dose. Keep out of the reach of young children.
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