Folate 5-MTHF 400mcg - 100 caps

Vitals Folate 5-MTHF 400 mcg is a dietary supplement containing folate in the biologically active form 5-methyltetrahydrofolate (5-MTHF). This is the body's natural form in which folate circulates in the blood. Folic acid (also known as vitamin B11) is the name for the synthetic pteroylmonoglutamic acid, which is used as a source of folate in common folic acid supplements.

The problem with synthetic folic acid is that in a relatively large group of people, the conversion to biologically active 5-MTHF is difficult, which means that supplementation may not be sufficiently effective and, moreover, an undesirable accumulation of unmetabolized folic acid can occur. For these reasons, Vitals exclusively uses Quatrefolic®.

Quatrefolic® was developed by the Italian manufacturer Gnosis. It consists of 5-MTHF bound to a glucosamine salt (from a vegetable source). This binding stabilizes the active folate and results in higher bioavailability than folate from food, synthetic folic acid, or 5-MTHF bound to calcium salt. The glucosamine salt form is highly soluble in water, allowing Quatrefolic® to be more easily absorbed by the cells in the intestinal wall.

Folate contributes to normal cell division and is involved in the formation of cells and tissues, including red and white blood cells. In homocysteine metabolism, 5-MTHF acts as a methyl donor to convert homocysteine to methionine. Methionine, in turn, is used for the production of S-adenosylmethionine (SAMe), which as a methyl donor is involved in the production of DNA, RNA, phospholipids, proteins, and neurotransmitters, among others. Folate is also necessary for normal brain and nerve functions.

During pregnancy (or when trying to conceive)

Folate is extra important for women who want to become pregnant or are already pregnant. Folate contributes to tissue growth during pregnancy and plays a role in the formation of the placenta and the normal growth of the unborn child. The advice to take folate before and during pregnancy is well known. It is necessary to start supplementation at least four weeks before conception and to continue until at least eight weeks after conception.

The following health claims have been approved by the European Food Safety Authority (EFSA):

• Folate supports the production of red and white blood cells.
• Folate plays a role in the production of cells and tissues.
• Folate plays a role in amino acid synthesis.
• Folate is good for homocysteine metabolism.
• Folate has a positive effect on the immune system.
• Folate contributes to normal psychological functioning.
• Folate can help reduce fatigue.
• Folate contributes to the formation of the placenta and the growth of the unborn child during pregnancy.
• 400 µg folate (Quatrefolic®) per capsule (200% RI)
• Biologically active form 5-MTHF, directly available to the body
• Quatrefolic®: fourth generation folate with higher bioavailability
• Contains the recommended dosage for use before and during pregnancy
• 100 capsules per jar (100 daily doses)
• 100% vegan

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Directions

Take 1 capsule daily with a meal and water. Do not exceed the recommended dosage.

Please note

For optimal efficacy, use Folate 5-MTHF with a vitamin B-complex and/or a multivitamin (due to synergy between B vitamins). It is important that for long-term use (> 3 months), the total daily intake of folate does not exceed 1000 mcg.

Storage advice

Store dry, sealed, and at room temperature. Keep out of reach of young children.

Plenthera Usage Tip

Take the capsule with breakfast with a glass of water. Preferably combine with a vitamin B-complex for optimal synergy between B vitamins.

Ingredients list (according to label)

Rice concentrate (Oryza sativa), vegetarian capsule (pullulan, from fermented cassava starch), rice extract (Oryza sativa), 5-methyltetrahydrofolate glucosamine salt.

Ingredient explanation

• 5-methyltetrahydrofolate glucosamine salt (Quatrefolic®) — biologically active form of folate
• Rice concentrate (Oryza sativa) — excipient
• Pullulan (from fermented cassava starch) — vegetarian capsule
• Rice extract (Oryza sativa) — excipient

Allergens

This product is free from gluten, soy, lactose, and nuts. It is 100% vegan.

Quality documentation

Certificate of analysis and laboratory tests for purity and heavy metals are available. Documentation can be provided upon request.

Transparency & quality control

• Ingredients are carefully selected and controlled
• Production takes place according to quality standards
• Laboratory tests check purity and heavy metals
• Certificates of analysis are available upon request
• Formulas contain no unnecessary additives

What is Quatrefolic®?

Quatrefolic® is the fourth generation of folate, developed by the Italian manufacturer Gnosis. It consists of 5-MTHF bound to a glucosamine salt from a plant source. This bond ensures stability and higher bioavailability than folate from food, synthetic folic acid, or 5-MTHF bound to calcium salt.

What is the difference between folic acid and 5-MTHF?

Folic acid is the synthetic form of folate (pteroylmonoglutamic acid). In a relatively large group of people, the conversion of folic acid to the biologically active 5-MTHF is difficult. 5-MTHF is the body's own form that is directly available to the body without conversion.

Why is folate important during pregnancy?

Folate contributes to tissue growth during pregnancy and plays a role in the formation of the placenta and the normal growth of the unborn child. It is recommended to start taking folate at least four weeks before conception and to continue until at least eight weeks after conception.

Can I combine this with other B vitamins?

Yes, this is even recommended. Folate works with other B vitamins, especially B6 and B12, in homocysteine metabolism. It is best to use Folate 5-MTHF with a vitamin B complex and/or a multivitamin.

What is the maximum amount of folate I can take?

For long-term use (> 3 months), it is important that the total daily intake of folate does not exceed 1000 mcg.

How long do 100 capsules last?

At the recommended daily dosage of 1 capsule, a jar of 100 capsules is sufficient for 100 days.

Is the product vegan?

Yes, the product is 100% vegan. The capsule is made from pullulan (plant-based, from fermented cassava starch).

What is homocysteine?

Homocysteine is an amino acid that is formed in metabolism. 5-MTHF acts as a methyl donor to convert homocysteine to methionine. A sufficient intake of folate is beneficial for homocysteine metabolism.

Vitals Voedingssupplementen BV

Pieter Lieftinckweg 29

1505 HX Zaandam

The Netherlands

Website: www.vitals.nl / www.vitals.eu

About Vitals

Vitals Voedingssupplementen BV is a Dutch manufacturer of nutritional supplements, located in Zaandam.