Written by the Plenthera team (orthomolecularly trained). Scientifically reviewed in April 2026. Last updated: April 30, 2026.
Nattokinase is perhaps the most remarkable enzyme in this category — a fibrinolytic enzyme from fermented soybean that can break down fibrin (blood clot protein). It was isolated in Japan in 1980 from natto, a traditional breakfast dish. At Plenthera, you'll find premium nattokinase in capsules with a standardized 2,000+ FU per serving. CRUCIAL NOTE: always consult a doctor beforehand if using blood thinners or before surgery.
Which nattokinase is right for you?
| Form | FU | Best for |
|---|---|---|
| Capsules 2000 FU | Standard | General cardiovascular |
| Capsules 4000 FU | High | Maximum effect (consult with doctor) |
| + serrapeptase | Variable | Premium fibrinolytic |
What is nattokinase?
Nattokinase is a fibrinolytic enzyme (fibrin-degrading) extracted from Japanese natto — fermented soybean by Bacillus subtilis natto. It was discovered in 1980 by Dr. Hiroyuki Sumi and has since been clinically studied for cardiovascular applications.
Natto is a Japanese breakfast dish with a distinctive taste, texture, and smell — made from fermented soybeans with the bacterium Bacillus subtilis natto. In 1980, Dr. Sumi isolated the enzyme nattokinase from this fermentation and demonstrated its fibrinolytic action — fibrin (the protein component of blood clots) was broken down in vitro. Since then, nattokinase has been extensively researched for cardiovascular applications.
In clinical research, nattokinase has been studied for blood pressure, fibrinogen levels, vascular function, and general cardiovascular support. Results have been positive in multiple studies, but EFSA has not recognized any claims. The main practical note: nattokinase affects the clotting system — therefore, medical caution is essential.
For those who want to approach cardiovascular research more broadly — in addition to omega 3, Q10, turmeric — nattokinase can be a logical addition. But only in consultation with a doctor if there are clotting disorders or if blood thinners are being used. See our omega 3 category and our turmeric category for related cardiovascular research categories.
Science, fibrinolysis, and EFSA status
Scientific research into nattokinase focuses on cardiovascular applications — fibrinolysis, blood pressure, fibrinogen levels, vascular function. Clinical research in humans shows positive results in small-scale studies, often with dosages of 100-200 mg per day.
Important: there are NO health claims recognized by EFSA for nattokinase. We therefore make no literal efficacy claims. Nattokinase is a dietary supplement, not a medicine.
CRUCIAL: if using blood thinners (warfarin, NOACs, aspirin), before surgery (avoid 2 weeks prior), with clotting disorders or bleeding diathesis: DO NOT use without medical consultation.
The nattokinase forms at Plenthera
Nattokinase 2000 FU capsules
Standard dosage — 100 mg per capsule with 2,000 FU. For general cardiovascular research.
Nattokinase 4000 FU capsules
Higher dosage — for those who want higher fibrinolytic activity. Premium price point.
Nattokinase + serrapeptase
Combination of two fibrinolytic enzymes — premium niche.
How to use nattokinase?
Simple basic approach for nattokinase:
- Take between meals for maximum systemic effect.
- Standard 100-200 mg/day (2,000-4,000 FU).
- If using blood thinners: medical consultation beforehand.
- Before surgery: stop at least 2 weeks prior.
- In case of doubt or medical context: consult a doctor.
Myths and misconceptions about nattokinase
Myth 1: "Nattokinase is a natural aspirin."
Half true — both have fibrinolytic / antithrombotic effects, but different mechanisms. Nattokinase is not a substitute for aspirin in a medical context.
Myth 2: "Everyone can safely take nattokinase."
Incorrect. With blood thinners, before surgery, during pregnancy or with bleeding diathesis: avoid or seek medical consultation.
Myth 3: "The more nattokinase, the better the cardiovascular effect."
Above 4,000 FU/day, no additional effect has been demonstrated, and bleeding risk increases.
Myth 4: "Eating fresh natto provides enough nattokinase."
For a wholefood route: yes, partly. For systemic clinical effect: dosage from food is usually too low — supplement is more effective.
Combining nattokinase with other supplements
Nattokinase is often combined for cardiovascular issues. Commonly chosen combinations:
- Omega 3: cardiovascular cluster with EFSA claim.
- Q10: mitochondrial and cardio.
- Magnesium: cardio-mineral.
- Turmeric: inflammation modulation.
- Vitamin K2: relevant — affects clotting, in a different direction than nattokinase. Best discussed with a doctor.
Frequently asked questions
What is nattokinase?
Fibrinolytic enzyme from Japanese natto.
How does nattokinase work?
Breaks down fibrin (blood clot protein), supports natural fibrinolysis.
How much nattokinase per day?
100-200 mg, 2,000-4,000 FU.
When to take nattokinase?
Between meals for systemic effect.
Can nattokinase be taken with blood thinners?
NOT without medical consultation — bleeding risk.
What is FU for nattokinase?
Fibrinolytic Units — unit for fibrinolytic activity.
Nattokinase for circulation?
Clinically studied. EFSA claim not recognized.
Difference between nattokinase and aspirin?
Different mechanisms — not interchangeable in a medical context.
Does nattokinase have side effects?
Possible: bleeding tendency with high dosages, especially with other antithrombotics.
Vegan nattokinase?
Yes — from soybean fermentation, plant-based.
Sources
- EFSA Regulation (EU) 432/2012 — no overarching enzyme claims; individual claims limited.
- Sumi H. et al., "A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto", Experientia (1987).
- Chen H. et al., "Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases", Biomark Insights (2018).
Disclaimer: This text is intended for informational purposes only and does not replace medical advice. Nattokinase is a dietary supplement, not a medicine. If in doubt or if taking medication, we recommend consulting a doctor or orthomolecular therapist first.