Written by the Plenthera team (orthomolecularly trained). Scientifically reviewed in April 2026. Last updated: April 30, 2026.
Cellulase is a remarkable enzyme — humans do NOT produce it themselves. The cellulose in plant fibers (vegetables, legumes, grains) is only broken down by gut flora, and for some people, this causes bloating and gas. Cellulase supplementation provides an additional fiber-breakdown pathway. Especially relevant for vegans and people experiencing discomfort after fiber-rich meals.
Which cellulase is right for you?
| Form | Best for |
|---|---|
| Loose | Specific fiber digestion |
| In enzyme complex | Plant-focused broad-spectrum |
What is cellulase?
Cellulase is an enzyme that breaks down cellulose (plant fiber) into simple sugars. Notably, humans do NOT produce cellulase themselves — fiber breakdown comes exclusively from gut flora fermentation. Cellulase supplements are microbial.
Unlike amylase, protease, and lipase, which the body produces itself, cellulase is entirely dependent on gut flora in humans. Those who eat a lot of plant fiber (vegans, vegetarians, legume enthusiasts) rely heavily on their own flora to break down cellulose. In cases of flora imbalance or heavy fiber load, this can cause bloating and gas.
Cellulase supplementation provides an additional cellulose breakdown pathway — not via gut flora but directly enzymatically. For those who regularly experience bloating after fiber-rich meals or a plant-based diet, this can make a difference.
Science and EFSA status
EFSA has not recognized a specific cellulase claim. Its function (cellulose breakdown) is scientifically documented.
The cellulase forms at Plenthera
Loose Cellulase (capsules)
For specific fiber digestion.
Cellulase in enzyme complex
Part of a plant-focused enzyme formula.
How to use cellulase?
Simple basic approach for cellulase:
- With fiber-rich/plant-based meals — 1-2 capsules.
- Specifically with beans or heavy vegetables.
- Combine with other enzymes for a complete plant-based diet package.
Myths and misconceptions about cellulase
Myth 1: "Everyone needs cellulase."
Not automatically. For those who have no complaints with fiber-rich foods: not necessary.
Myth 2: "Cellulase works on all fibers."
Specifically on cellulose. Other fibers (pectin, beta-glucans) require other enzymes.
Myth 3: "Cellulase eliminates bloating."
Helps with cellulose-related complaints. For other causes (FODMAPs, lactose, gluten), it is not effective.
Combining cellulase with other supplements
Cellulase is often combined. Popular combinations:
- Digestive enzyme complex with cellulase: broad plant-based coverage. View our digestive enzymes category.
- Probiotics: for flora support. View our probiotics category.
- Psyllium husk: for those approaching the fiber topic more broadly. View our psyllium husk category.
- Vegan protein: for a plant-based sports cluster. View our vegan protein category.
Frequently Asked Questions
What is cellulase?
Enzyme that breaks down plant fiber/cellulose.
Does the body produce cellulase?
NO — only gut flora does.
When to take cellulase?
With fiber-rich/plant-based meals.
Cellulase for vegans?
Logical — a plant-based diet means a lot of cellulose.
How much cellulase per day?
Follow label.
Does cellulase help with bloating?
Yes, for cellulose-related complaints.
Plant-based cellulase?
Microbial — vegan-friendly.
Does cellulase have side effects?
Generally well tolerated.
Cellulase for beans?
Beans also contain other carbohydrates (oligosaccharides) — cellulase alone does not solve everything. Beano and complex are often more effective for beans.
Cellulase for IBS?
Can help with IBS with fiber-related complaints. Consult a doctor.
Sources
- EFSA Regulation (EU) 432/2012 — no overarching enzyme claims; individual claims limited.
- Roxas M., "The role of enzyme supplementation in digestive disorders", Altern Med Rev (2008).
- EFSA — Scientific Opinions on enzyme claims (mostly rejected or not evaluated).
Disclaimer: This text is for informational purposes only and does not replace medical advice. Cellulase is a dietary supplement, not a medicine. In case of doubt or if you are taking medication, we recommend consulting a doctor or orthomolecular therapist first.