Written by the Plenthera team (orthomolecularly trained). Scientifically reviewed in May 2026. Last updated: 28 May 2026.

Enzymes are catalysts — proteins that accelerate specific biochemical reactions without being consumed. The human body produces thousands, but the enzyme supplement category focuses on two groups: digestive enzymes (bromelain, papain, amylase, lipase, protease, lactase) and systemic enzymes (nattokinase, serrapeptase, lumbrokinase) which are taken on an empty stomach for circulation and tissue support.

On this pageDigestive enzymes — what for and when? · Systemic enzymes — taken on an empty stomach · Our enzyme sub-categories and brands · Frequently asked questions · Combine with · Sources

Digestive enzymes — what for and when?

Digestive enzymes help break down carbohydrates (amylase), fats (lipase), proteins (protease), and fibers (cellulase). Useful for discomfort after heavy meals, weak stomach acid function (especially with age), or specific intolerances (lactase for lactose, bromelain and papain as plant-based protease sources).

Intake: usually just before or at the beginning of a meal, 1-2 capsules. For heavy meals, possibly 2 capsules; for light snacks, not necessary.

Systemic enzymes — taken on an empty stomach

Systemic enzymes (nattokinase, serrapeptase, lumbrokinase) are taken on an empty stomach — at least 30 minutes before or 2 hours after a meal — so they are not used for food digestion but can work systemically on fibrin and circulation.

Nattokinase

Derived from natto (fermented soy product). Studied for fibrin breakdown and circulatory support. Often used in dosages of 2,000 FU per day.

Serrapeptase

A protease extracted from Serratia bacteria. Studied for inflammation modulation and recovery.

Lumbrokinase

More powerful systemic enzyme, originally isolated from earthworms. Primarily studied for circulatory applications.

Our enzyme sub-categories and brands

• Digestive Enzymes — broad enzyme blends for optimal food digestion
• Bromelain — from pineapple — protein digestion and inflammation modulation
• Amylase — for carbohydrate digestion
• Lipase — for fat digestion
• Protease — for protein digestion
• Lactase — for those who have difficulty tolerating lactose
• Nattokinase — systemic enzyme from natto, for circulatory support
• Lumbrokinase — powerful systemic fibrin enzyme
• Arthur Andrew Medical — American enzyme specialist brand (Neprinol, Serretia, Devigest)

Frequently asked questions

What is the difference between digestive and systemic enzymes?

Digestive enzymes are taken with meals to break down food in the digestive tract. Systemic enzymes are taken on an empty stomach — they are absorbed and work in the blood/tissues on fibrin, inflammation, and circulation.

When should I take digestive enzymes?

Just before or at the beginning of a meal. For heavy (protein or fat-rich) meals, enzymes have the most effect.

Are enzymes safe for long-term use?

Digestive enzymes are generally considered safe. Systemic enzymes (nattokinase, serrapeptase, lumbrokinase) are not recommended when using blood thinners or before surgery — always consult a doctor.

What does bromelain do?

Bromelain is a protease from pineapple. With meals, it helps digest proteins; taken on an empty stomach, it is studied for inflammation modulation and recovery after exercise.

Can I combine enzymes with other supplements?

Digestive enzymes work well with probiotics (complete digestive package). Do not combine systemic enzymes with blood thinners. If in doubt: ask your doctor or pharmacist.

Which brand of enzymes is best?

Arthur Andrew Medical (AAM) specializes in enzyme formulas with standardized activity units (FU, SPU, GDU). Vitals and NOW Foods also supply reliable digestive enzymes.

Combine with other categories

Enzymes often work in synergy with other gut and recovery supplements:

• Digestion & Gut — for probiotics, prebiotics, and gut recovery
• Probiotics — complementary to digestive enzymes
• Amino Acids — for those who have difficulty breaking down protein
• Heart & Vessels — for nattokinase and circulatory support

Sources & references

• Roxas (2008) — Role of enzyme supplementation in digestive disorders (Altern Med Rev)
• Maurer (2001) — Bromelain: biochemistry, pharmacology and medical use (Cell Mol Life Sci)
• Tian et al. (2024) — Nattokinase clinical applications review
• Voedingscentrum — food digestion and enzymes

Disclaimer: This text is for informational purposes only and does not replace medical advice. Nutritional supplements are not a substitute for a varied, balanced diet and a healthy lifestyle. If in doubt, always consult your doctor or an orthomolecular therapist.